Great Dane Members - DogsArk: The ICB Breeder Tool

Genetic Diversity

Great Dane Inbreeding

wdt_ID	ICB Code	Inbreeding (F)	Inbreeding (Fis)	Mean Kinship (mK)	Heterozygosity (Ho)
1	GrtD-1001	0.323	0.193	0.157	0.226
2	GrtD-1002	0.206	0.131	0.059	0.244
3	GrtD-1003	0.191	-0.005	0.114	0.281
4	GrtD-1004	0.199	-0.013	0.125	0.284
5	GrtD-1005	0.181	-0.032	0.139	0.289
6	GrtD-1006	0.325	-0.040	0.116	0.291
7	GrtD-1007	0.196	0.135	0.050	0.242
8	GrtD-1008	0.394	-0.019	0.139	0.286
9	GrtD-1009	0.322	0.229	0.133	0.216
10	GrtD-1010	0.389	0.127	0.061	0.245
11	GrtD-1011	0.268	0.230	0.062	0.216
12	GrtD-1012	0.204	0.072	0.129	0.260
13	GrtD-1013	0.450	-0.016	0.098	0.285
14	GrtD-1014	0.354	0.295	0.127	0.198
15	GrtD-1015	0.202	0.163	0.171	0.234
16	GrtD-1016	0.263	-0.011	0.116	0.283
17	GrtD-1017	0.232	0.050	0.123	0.266
18	GrtD-1018	0.395	0.018	0.170	0.275
19	GrtD-1019	0.480	0.230	0.160	0.216
20	GrtD-2001	0.349	0.327	0.144	0.189

Genetic Structure

The dendrogram and heat map for genetic structure are produced from the kinship coefficients.

Kinship Coefficient

The kinship coefficient (K) is the fraction of the genome shared by two individuals that is homozygous by descent, so it is a pairwise measure of relatedness.

This kinship matrix is color coded to identify cells in which K < 0.0625 (6.25%; green, equivalent to a cross of first cousins), K = 0.125 (12.5%; yellow, half-sib cross), and K > 0.25 (25%; red, full sib cross). The kinship coefficient between a male and female is also the predicted average inbreeding coefficient of their offspring if they produced a litter.

Runs of Homozygosity (ROH)

Inbreeding tends to produce runs (blocks) of homozygosity (ROH) on the chromosomes. Over time, the crossing-over of chromosomes during meiosis can split up blocks of homozygosity, so the largest blocks are likely to be the most recent inbreeding and smaller blocks reflect older inbreeding. ROH are used to estimate inbreeding from SNP data.

Learn more about Runs of Homozygosity.

Inbreeding: 25 generations (1000 kb)